Data Release - The Cancer Dependency Map (DepMap) Project

March 03, 2026

The Broad Institute's Cancer Dependency Map (DepMap) project has expanded its data accessibility paradigm by making its comprehensive sequencing data available through AnVIL on Terra, NHGRI's Genomic Data Science Analysis, Visualization, and Informatics Lab-Space. Whole-genome sequencing (WGS), whole exome sequencing (WES) and RNA sequencing (RNA) generated by the project is now available on AnVIL’s secure platform with controlled access restrictions, including Health/Medical/Biomedical (HMB) and Methods Development (MDS). New data will be added to the DepMap AnVIL datasets as it becomes available on the DepMap portal in the future. The DepMap team is excited to enable more researchers to leverage this resource to drive progress in understanding cancer dependencies and developing effective treatments.

Access requests for this controlled data are available through dbGaP under accession phs003444.v3.p1 and the data is available at https://explore.anvilproject.org/datasets or https://duos.org/datalibrary/anvil.

The DepMap project is committed to systematically accelerating precision cancer medicine by developing comprehensive, large-scale functional datasets that are publicly accessible to the research community. DepMap genomically profiles large panels of human cancer models using WGS, WES and RNA sequencing, and other omics modalities. The project employs genome-wide CRISPR knockout screening and drug sensitivity testing in barcoded cell lines to discover new targets and biomarkers for precision cancer therapy.

Launched in 2017 at the Broad Institute, and building off the Cancer Cell Line Encyclopedia (CCLE) (PMID:31068700) and Project Achilles, the DepMap project aimed to provide widespread insights into how specific genes influence cancer cell survival and response to treatments (PMID:28753430). The DepMap project continues to expand, integrating genomic, transcriptomic, and drug response data, and has become a vital resource for the cancer research community (PMID:39468210). DepMap’s collaborative approach encourages contributions from researchers worldwide, fostering innovation and discovery in cancer treatment strategies. To further advance this mission, the Broad established the DepMap Consortium - an industry/academic partnership dedicated to expanding DepMap's capabilities to accelerate precision cancer medicine.

Processed DepMap data and analyses are free and available to be explored on the DepMap.org portal.

Available Data

50X Whole Exome sequencing
30X Whole Genome sequencing
100X RNA sequencing
Associated model characteristics (metadata) as available on DepMap.org

Help us make these docs great!

All AnVIL docs are open source. See something that’s wrong or unclear? Submit a pull request.

Make a contribution