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NHLBI TOPMed - NHGRI CCDG: Groningen Genetics of Atrial Fibrillation (GGAF) Study

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Atrial fibrillation (also called AFib or AF) is a quivering or irregular heartbeat (arrhythmia) that can lead to blood clots, stroke, heart failure and other heart-related complications. The Groningen Genetics of Atrial Fibrillation (GGAF) cohort is a cohort composed from 5 different sources of individuals with atrial fibrillation (AF) and age and sex-matched controls. Written informed consent was provided from all participating individuals, and all 5 studies were approved by the ethical committee at the University Medical Center ( and Maastricht University. All samples selected for TOPMed WGS are from individuals with atrial fibrillation.

PlatformsAnVIL, BDC

Consent Codes


Focus / Diseases

Atrial Fibrillation

Study Design

Prospective Longitudinal Cohort

Data Types

SNP/CNV Genotypes (NGS), WGS