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Pancreas Cancer Organoid Profiling

phs001611.v1.p1dbGapdbGap FHIR

Description

We generated a collection of patient-derived pancreatic normal and cancer organoids. We performed whole genome sequencing, targeted exome sequencing, and RNA sequencing on organoids as well as matched tumor and normal tissue if available. This dataset is a valuable resource for pancreas cancer researchers, and those looking to compare primary tissue to organoid culture. In our linked publication, we show that pancreatic cancer organoids recapitulate the mutational spectrum of pancreatic cancer. Furthermore, RNA sequencing of organoids demonstrates the presence of both transcriptional subtypes of pancreas cancer.

Summary

PlatformsCRDC
Consent CodesGRU
Focus / DiseasesNeoplasms
Study DesignProspective Longitudinal Cohort
Data Types--
Subjects71