Genetics Consortium for Late Onset of Alzheimer's Disease (LOAD CIDR Project)
Multiplex Family Study
The purpose of the NIA Genetics Initiative: Multiplex Family Study is to identify families with
multiple members diagnosed with late-onset Alzheimer's Disease. Families will be characterized clinically and blood samples will be
collected to establish cell lines. If a blood sample is not available, autopsy samples will be collected for DNA extraction and storage.
Our goal is to recruit 1,000 families over the course of the study. Clinical and demographic data from these families will be
collected at the local site and coded data, without identifiers, will be sent and included in a national database of families
with Alzheimer's Disease. This database, along with the biological samples, will be housed at the National Cell
Repository for Alzheimer's Disease (NCRAD) at Indiana University. The Center or provider and the Cell Repository must sign a
Material Transfer Agreement for shipment of biological samples and phenotypic data to NCRAD. The biological samples and data from
these families will be available to qualified researchers, who must sign a Material Transfer Agreement before receiving DNA and data.
An oversight committee known as the Cell Bank Advisory Committee (CBAC) will review and monitor the process of family identification
and enrollment, data collection, the establishment of cell lines and access to samples.
LOAD CIDR Project
The first 362 families of the Multiplex Family Study (including 2,105 family members) were included in a
6K SNP genome-wide scan at the NIH-supported, Center for Inherited Disease Research (CIDR). An additional 297 unrelated, healthy controls
were also genotyped at CIDR. The average age of onset of AD in the genotyped sample is 74 years and 62% of the sample is women. While
primarily Caucasian, 3% are African-American, and 3% are of Hispanic ancestry. 72% of the families had at least 2 affected siblings,
whereas 21% had 3 or more sampled affected individuals and 7% had 4 or more genotyped, affected family members.