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Center for Common Disease Genomics [CCDG] - Autoimmune: Inflammatory Bowel Disease (IBD) Exomes and Genomes

CCDGphs001642.v1.p1dbGapdbGap FHIR

Description

The National Human Genome Research Institute (NHGRI) has funded a collaborative large-scale genome sequencing effort to comprehensively identify rare risk and protective variants contributing to multiple common disease phenotypes. Called the Centers for Common Disease Genomics (CCDG), this initiative will explore a range of diseases with the ultimate goal of: undertaking variant discovery for enough different examples of disease architectures and study designs to better understand the general principles of the genomic architecture underlying common, complex inherited diseases; understanding how best to design rare variant studies for common disease; developing resources, informatics tools, and innovative approaches and technologies for multiple disease research communities and the wider biomedical research community. The initial focus of the CCDGs will be in cardiovascular disease (early-onset coronary artery disease, atrial fibrillation, hemorrhagic stroke), neuropsychiatric disease (epilepsy, autism), and autoimmune/inflammatory disease (type 1 diabetes, inflammatory bowel disease). The Broad Institute is one of four selected CCDG project centers. The overarching aim of the Inflammatory Bowel Disease (IBD) program is to define the full allelic spectrum of protein-altering variation in genes associated to IBD, and assess their role in both Crohn's Disease (CD) and Ulcerative Colitis (UC) risk. The whole genome sequencing data generated here is comprised of samples from US-based diverse populations including African American, Puerto-Rican, Caribean and Cuban origins.

Stats

42Cohorts
55,468Samples
55,300Participants
95.62 TBSize

Summary

Consent CodesGRU, HMB, DS-IBD, TBD, NA, DS-GID
Diseasesinflammatory bowel disease, IBD
AccessControlled Access, Consortium Access Only
Study DesignCase-Control, TBD
Data TypesExome, Whole Genome, Genotyping Array

Applying For Access

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Terra Workspaces

This study has been divided into the following workspaces by consent codes and optionally the originating laboratory.

Terra Workspace NameConsent CodeDiseaseAccessStudy DesignData TypeSamplesParticipantsSize (TB)
anvil_ccdg_broad_ai_ibd_alm_gmc_wesGRUinflammatory bowel diseaseCase-ControlExome9159150.99
AnVIL_CCDG_Broad_AI_IBD_Brant_DS-IBD_WGSHMBinflammatory bowel diseaseCase-ControlWhole Genome1991992.61
AnVIL_CCDG_Broad_AI_IBD_Brant_HMB_WGSHMBinflammatory bowel diseaseCase-ControlWhole Genome90490412.44
AnVIL_CCDG_Broad_AI_IBD_Cho_WGSDS-IBDinflammatory bowel diseaseCase-ControlWhole Genome3443455.34
anvil_ccdg_broad_ai_ibd_daly_alm_gmc_gsaTBDinflammatory bowel diseaseCase-ControlGenotyping Array9429250.16
anvil_ccdg_broad_ai_ibd_daly_bernstein_gsaTBDinflammatory bowel diseaseTBDGenotyping Array5375360.09
anvil_ccdg_broad_ai_ibd_daly_brant_niddk_gsaTBDinflammatory bowel diseaseCase-ControlGenotyping Array1,0771,0710.19
anvil_ccdg_broad_ai_ibd_daly_burnstein_gsaTBDinflammatory bowel diseaseCase-ControlGenotyping Array68680.01
anvil_ccdg_broad_ai_ibd_daly_burnstein_utsw_wesTBDinflammatory bowel diseaseTBDExome65650.06
anvil_ccdg_broad_ai_ibd_daly_chen_gsaTBDinflammatory bowel diseaseCase-ControlGenotyping Array15150.00
anvil_ccdg_broad_ai_ibd_daly_chen_wesTBDinflammatory bowel diseaseTBDExome21210.02
anvil_ccdg_broad_ai_ibd_daly_cho_niddk_gsaTBDinflammatory bowel diseaseCase-ControlGenotyping Array1,7861,7860.31
anvil_ccdg_broad_ai_ibd_daly_chung_gider_gsaTBDinflammatory bowel diseaseTBDGenotyping Array6286280.11
anvil_ccdg_broad_ai_ibd_daly_duerr_niddk_gsaTBDinflammatory bowel diseaseCase-ControlGenotyping Array1,9481,8390.33
anvil_ccdg_broad_ai_ibd_daly_faubion_share_gsaTBDinflammatory bowel diseaseTBDGenotyping Array9069050.16
anvil_ccdg_broad_ai_ibd_daly_franchimont_gsaTBDinflammatory bowel diseaseCase-ControlGenotyping Array2,8262,8240.48
anvil_ccdg_broad_ai_ibd_daly_kastner_fmf_gsaTBDinflammatory bowel diseaseCase-ControlGenotyping Array27270.01
anvil_ccdg_broad_ai_ibd_daly_lewis_sparc_gsaTBDinflammatory bowel diseaseCase-ControlGenotyping Array2,8632,8630.49
anvil_ccdg_broad_ai_ibd_daly_lira_share_wesTBDinflammatory bowel diseaseTBDExome55550.09
anvil_ccdg_broad_ai_ibd_daly_mccauley_gsaTBDinflammatory bowel diseaseCase-ControlGenotyping Array1,6421,6420.28
anvil_ccdg_broad_ai_ibd_daly_mcgovern_gsaTBDinflammatory bowel diseaseCase-ControlGenotyping Array6,0886,0881.04
anvil_ccdg_broad_ai_ibd_daly_mcgovern_niddk_wesTBDinflammatory bowel diseaseCase-ControlExome8,5188,51810.03
anvil_ccdg_broad_ai_ibd_daly_mcgovern_share_wesTBDinflammatory bowel diseaseTBDExome4844840.66
anvil_ccdg_broad_ai_ibd_daly_moayyedi_imagine_gsaNAIBDCase-ControlGenotyping Array2,5502,5500.44
anvil_ccdg_broad_ai_ibd_daly_newberry_share_gsaTBDinflammatory bowel diseaseTBDGenotyping Array8698690.15
anvil_ccdg_broad_ai_ibd_daly_pekow_share_gsaTBDinflammatory bowel diseaseTBDGenotyping Array7067060.12
anvil_ccdg_broad_ai_ibd_daly_pekow_share_wesTBDinflammatory bowel diseaseTBDExome5865860.54
anvil_ccdg_broad_ai_ibd_daly_rioux_igenomed_gsaTBDinflammatory bowel diseaseCase-ControlGenotyping Array1861860.03
anvil_ccdg_broad_ai_ibd_daly_rioux_igenomed_wesTBDinflammatory bowel diseaseTBDExome1821820.17
anvil_ccdg_broad_ai_ibd_daly_rioux_niddk_gsaTBDinflammatory bowel diseaseCase-ControlGenotyping Array9199150.16
anvil_ccdg_broad_ai_ibd_daly_rioux_niddk_wesTBDinflammatory bowel diseaseCase-ControlExome1,7071,7052.59
anvil_ccdg_broad_ai_ibd_daly_sands_msccr_gsaTBDinflammatory bowel diseaseCase-ControlGenotyping Array1,4641,4640.25
anvil_ccdg_broad_ai_ibd_daly_sands_msccr_wesTBDinflammatory bowel diseaseTBDExome1,4351,4351.22
anvil_ccdg_broad_ai_ibd_daly_sartor_share_wesTBDinflammatory bowel diseaseTBDExome51510.09
anvil_ccdg_broad_ai_ibd_daly_silverberg_niddk_gsaTBDinflammatory bowel diseaseCase-ControlGenotyping Array2,4402,4170.42
anvil_ccdg_broad_ai_ibd_daly_vermeire_gsaTBDinflammatory bowel diseaseTBDGenotyping Array4,8514,8500.83
anvil_ccdg_broad_ai_ibd_daly_xavier_kastner_fmf_wesTBDinflammatory bowel diseaseTBDExome27270.02
anvil_ccdg_broad_ai_ibd_daly_xavier_share_gsaTBDinflammatory bowel diseaseTBDGenotyping Array7097060.12
AnVIL_CCDG_Broad_AI_IBD_Kugathasan_WGSGRUinflammatory bowel diseaseCase-ControlWhole Genome1,3511,35117.29
AnVIL_CCDG_Broad_AI_IBD_McCauley_WGSHMBinflammatory bowel diseaseCase-ControlWhole Genome91391311.53
AnVIL_CCDG_Broad_AI_IBD_McGovern_WGSGRUinflammatory bowel diseaseCase-ControlWhole Genome1,6331,63323.39
AnVIL_CCDG_Broad_AI_IBD_Newberry_WGSDS-GIDinflammatory bowel diseaseCase-ControlWhole Genome31310.39