NHLBI TOPMed - NHGRI CCDG: MGH Atrial Fibrillation Study

Description

The Massachusetts General Hospital (MGH) Atrial Fibrillation Study was initiated in 2001. The study has enrolled serial probands, unaffected and affected family members with atrial fibrillation. At enrollment participants undergo a structured interview to systematically capture their past medical history, AF treatments, and family history. An electrocardiogram is performed; the results of an echocardiogram are obtained; and blood samples are obtained.

For the TOPMed WGS project only early-onset atrial fibrillation cases were sequenced. Early-onset atrial fibrillation was defined as an age of onset prior to 66 years of age.

Comprehensive phenotypic and pedigree data for study participants are available through dbGaP phs001001.

Stats

2Cohorts

486Samples

486Participants

2.38 TBSize

Summary

Consent CodesTBD, Consortia Access Only

Diseasesatrial fibrillation, cardiovascular system disease

AccessControlled Access, Consortium Access Only

Study DesignCase-Control, Case Set

Data TypesGenotyping Array, Whole Genome

Applying For Access

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Terra Workspaces

This study has been divided into the following workspaces by consent codes and optionally the originating laboratory.

Terra Workspace Name	Consent Code	Disease	Access	Study Design	Data Type	Samples	Participants	Size (TB)
AnVIL_CCDG_Broad_CVD_AF_Ellinor_MGH_Arrays	TBD	atrial fibrillation	Controlled Access	Case-Control	Genotyping Array	381	381	0.07
AnVIL_CCDG_Broad_CVD_AFib_MGH_WGS	Consortia Access Only	cardiovascular system disease	Consortium Access Only	Case Set	Whole Genome	105	105	2.32