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Autism Sequencing Consortium (ASC)

CCDGphs000298.v4.p3dbGapdbGap FHIR

Description

The ARRA Autism Sequencing Collaboration was created in 2010 bringing together expert large-scale sequencing center (at the Baylor College of Medicine, PI Richard Gibbs and the Board Institute of MIT and Harvard, PI Mark J. Daly) and a collaborative network of research labs focused on the genetics of autism (brought together by the Autism Genome Project and the Autism Consortium). These groups worked together to utilize dramatic new advances in DNA sequencing technology to reveal the genetic architecture of autism through comprehensive examination of the exotic sequence of all genes. The Autism Sequencing Consortium (ASC) was founded by Joseph D. Buxbaum and colleagues as an international group of scientists who share autism spectrum disorder (ASD) samples and genetic data. The PIs are Drs. Joseph D. Buxbaum (Icahn School of Medicine at Mount Sinai), Mark J. Daly (Broad Institute of MIT and Harvard), Bernie Devlin (University of Pittsburgh School of Medicine), Kathryn Roeder (Carnegie Mellon University, Matthew State and Stephan Sanders (University of California, San Francisco). The rationale for the ASC is described in Buxbaum et al. 2012, and this paper should be cited when referencing the data set. All shared data and analysis is hosted at a single site, which enables joint analysis of large-scale data from many groups. The ASC was first supported by a cooperative agreement grant to four lead sites funded by the National Institute of Mental Health (U01MH100233, U01MH100209, U01MH100229, U01MH100239), with additional support from the National Human Genome Research Institute. The NIMH recently renewed their support with a second grant (U01MH111661, U01MH111660, U01MH111658 and U01MH111662) to expand the project from 29,000 genomes to more than 50,000 exomes over the next 5 years. NHGRI provides ongoing sequencing support for the ASD through the Broad Center for Common Disease Genomics (UM1HG008895, Mark Daly, PI).

Stats

24Cohorts
20,915Samples
20,887Participants
30.40 TBSize

Summary

Consent CodesGRU, TBD, DS-ASD, HMB, GRU-NPU, DS-MH
Diseasesautism spectrum disorder
AccessControlled Access
Study DesignFamily/Twins/Trios, TBD, Case-Control
Data TypesExome, Genotyping Array, Whole Genome

Applying For Access

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Terra Workspaces

This study has been divided into the following workspaces by consent codes and optionally the originating laboratory.

Terra Workspace NameConsent CodeDiseaseAccessStudy DesignData TypeSamplesParticipantsSize (TB)
AnVIL_ccdg_asc_ndd_daly_talkowski_barbosa_asd_exomeGRUautism spectrum disorderFamily/Twins/TriosExome2132130.35
AnVIL_ccdg_asc_ndd_daly_talkowski_brusco_asd_exomeGRUautism spectrum disorderFamily/Twins/TriosExome2,2312,2312.87
AnVIL_ccdg_asc_ndd_daly_talkowski_CDCSEED_asd_exomeTBDautism spectrum disorderTBDExome2,9092,9092.67
anvil_ccdg_asc_ndd_daly_talkowski_cdcseed_asd_gsa-mdTBDautism spectrum disorderCase-ControlGenotyping Array2,8822,8820.49
AnVIL_ccdg_asc_ndd_daly_talkowski_chung_asd_exomeDS-ASDautism spectrum disorderFamily/Twins/TriosExome5235230.83
AnVIL_ccdg_asc_ndd_daly_talkowski_control_NIMH_asd_exomeGRUautism spectrum disorderFamily/Twins/TriosExome3703700.96
AnVIL_ccdg_asc_ndd_daly_talkowski_goethe_asd_exomeDS-ASDautism spectrum disorderFamily/Twins/TriosExome2,1112,1112.55
anvil_ccdg_asc_ndd_daly_talkowski_gurrieri_asd_exomeTBDautism spectrum disorderCase-ControlExome55550.04
AnVIL_ccdg_asc_ndd_daly_talkowski_hertz-picciotto_asd_exomeDS-ASDautism spectrum disorderFamily/Twins/TriosExome1,5371,5372.56
AnVIL_ccdg_asc_ndd_daly_talkowski_hertz-picciotto_asd_wgsDS-ASDautism spectrum disorderFamily/Twins/TriosWhole Genome65651.05
AnVIL_ccdg_asc_ndd_daly_talkowski_IBIS_asd_exomeTBDautism spectrum disorderTBDExome2372370.22
AnVIL_ccdg_asc_ndd_daly_talkowski_kolevzon_asd_exomeGRUautism spectrum disorderFamily/Twins/TriosExome1,1601,1601.54
AnVIL_ccdg_asc_ndd_daly_talkowski_kolevzon_asd_wgsGRUautism spectrum disorderFamily/Twins/TriosWhole Genome27270.47
AnVIL_ccdg_asc_ndd_daly_talkowski_mayo_asd_exomeTBDautism spectrum disorderTBDExome1451170.12
AnVIL_ccdg_asc_ndd_daly_talkowski_menashe_asd_exomeDS-ASDautism spectrum disorderFamily/Twins/TriosExome7017010.74
AnVIL_ccdg_asc_ndd_daly_talkowski_parellada_asd_exomeDS-ASDautism spectrum disorderFamily/Twins/TriosExome2,8242,8244.29
AnVIL_ccdg_asc_ndd_daly_talkowski_passos-bueno_asd_exomeDS-ASDautism spectrum disorderFamily/Twins/TriosExome9419411.31
AnVIL_ccdg_asc_ndd_daly_talkowski_pericak-vance_asd_exome_TBDautism spectrum disorderTBDExome1081080.17
AnVIL_ccdg_asc_ndd_daly_talkowski_pericak-vance_asd_wgsHMBautism spectrum disorderFamily/Twins/TriosWhole Genome2952955.22
AnVIL_ccdg_asc_ndd_daly_talkowski_persico_asd_exomeGRU-NPUautism spectrum disorderFamily/Twins/TriosExome4714710.78
AnVIL_ccdg_asc_ndd_daly_talkowski_renieri_asd_exomeDS-MHautism spectrum disorderFamily/Twins/TriosExome7657650.94
AnVIL_ccdg_asc_ndd_daly_talkowski_schloesser_asd_exomeTBDautism spectrum disorderTBDExome1521520.14
anvil_ccdg_asc_ndd_daly_talkowski_schloesser_asd_gsa-mdTBDautism spectrum disorderCase-ControlGenotyping Array1521520.03
AnVIL_ccdg_asc_ndd_daly_talkowski_weiss_asd_exomeDS-ASDautism spectrum disorderFamily/Twins/TriosExome41410.04