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Autism Sequencing Consortium (ASC)

CCDGphs000298.v4.p3dbGapdbGap FHIR

Description

The ARRA Autism Sequencing Collaboration was created in 2010 bringing together expert large-scale sequencing center (at the Baylor College of Medicine, PI Richard Gibbs and the Board Institute of MIT and Harvard, PI Mark J. Daly) and a collaborative network of research labs focused on the genetics of autism (brought together by the Autism Genome Project and the Autism Consortium). These groups worked together to utilize dramatic new advances in DNA sequencing technology to reveal the genetic architecture of autism through comprehensive examination of the exotic sequence of all genes. The Autism Sequencing Consortium (ASC) was founded by Joseph D. Buxbaum and colleagues as an international group of scientists who share autism spectrum disorder (ASD) samples and genetic data. The PIs are Drs. Joseph D. Buxbaum (Icahn School of Medicine at Mount Sinai), Mark J. Daly (Broad Institute of MIT and Harvard), Bernie Devlin (University of Pittsburgh School of Medicine), Kathryn Roeder (Carnegie Mellon University, Matthew State and Stephan Sanders (University of California, San Francisco). The rationale for the ASC is described in Buxbaum et al. 2012, and this paper should be cited when referencing the data set. All shared data and analysis is hosted at a single site, which enables joint analysis of large-scale data from many groups. The ASC was first supported by a cooperative agreement grant to four lead sites funded by the National Institute of Mental Health (U01MH100233, U01MH100209, U01MH100229, U01MH100239), with additional support from the National Human Genome Research Institute. The NIMH recently renewed their support with a second grant (U01MH111661, U01MH111660, U01MH111658 and U01MH111662) to expand the project from 29,000 genomes to more than 50,000 exomes over the next 5 years. NHGRI provides ongoing sequencing support for the ASD through the Broad Center for Common Disease Genomics (UM1HG008895, Mark Daly, PI).

Stats

16Cohorts
14,330Samples
13,233Participants
26.54 TBSize

Summary

Consent CodesGRU, DS-ASD, HMB, GRU-NPU, DS-MH
Diseasesautism spectrum disorder
AccessControlled Access
Study DesignCase-Control
Data TypesExome, Whole Genome

Terra Workspaces

This study has been divided into the following workspaces by consent codes and optionally the originating laboratory.

Terra Workspace NameConsent CodeDiseaseAccessStudy DesignData TypeSamplesParticipantsSize (TB)
AnVIL_ccdg_asc_ndd_daly_talkowski_barbosa_asd_exomeGRUautism spectrum disorderCase-ControlExome2132130.35
AnVIL_ccdg_asc_ndd_daly_talkowski_brusco_asd_exomeGRUautism spectrum disorderCase-ControlExome2,2311,9332.87
AnVIL_ccdg_asc_ndd_daly_talkowski_chung_asd_exomeDS-ASDautism spectrum disorderCase-ControlExome5235150.83
AnVIL_ccdg_asc_ndd_daly_talkowski_control_NIMH_asd_exomeGRUautism spectrum disorderCase-ControlExome3703700.96
AnVIL_ccdg_asc_ndd_daly_talkowski_goethe_asd_exomeDS-ASDautism spectrum disorderCase-ControlExome2,1111,9652.55
AnVIL_ccdg_asc_ndd_daly_talkowski_hertz-picciotto_asd_exomeDS-ASDautism spectrum disorderCase-ControlExome1,5371,5372.56
AnVIL_ccdg_asc_ndd_daly_talkowski_hertz-picciotto_asd_wgsDS-ASDautism spectrum disorderCase-ControlWhole Genome65651.05
AnVIL_ccdg_asc_ndd_daly_talkowski_kolevzon_asd_exomeGRUautism spectrum disorderCase-ControlExome1,1601,1281.54
AnVIL_ccdg_asc_ndd_daly_talkowski_kolevzon_asd_wgsGRUautism spectrum disorderCase-ControlWhole Genome27270.47
AnVIL_ccdg_asc_ndd_daly_talkowski_menashe_asd_exomeDS-ASDautism spectrum disorderCase-ControlExome7015570.74
AnVIL_ccdg_asc_ndd_daly_talkowski_parellada_asd_exomeDS-ASDautism spectrum disorderCase-ControlExome2,8242,7414.29
AnVIL_ccdg_asc_ndd_daly_talkowski_passos-bueno_asd_exomeDS-ASDautism spectrum disorderCase-ControlExome9417521.31
AnVIL_ccdg_asc_ndd_daly_talkowski_pericak-vance_asd_wgsHMBautism spectrum disorderCase-ControlWhole Genome2952955.22
AnVIL_ccdg_asc_ndd_daly_talkowski_persico_asd_exomeGRU-NPUautism spectrum disorderCase-ControlExome5264710.82
AnVIL_ccdg_asc_ndd_daly_talkowski_renieri_asd_exomeDS-MHautism spectrum disorderCase-ControlExome7656230.94
AnVIL_ccdg_asc_ndd_daly_talkowski_weiss_asd_exomeDS-ASDautism spectrum disorderCase-ControlExome41410.04